597 papers
This study identifies the GPI-anchored protease MT4-MMP as a critical regulator of embryonic brain angiogenesis that maintains vascular balance by cleaving the co-receptor NRP1 to modulate VEGFA-induced ERK signaling, thereby preventing excessive vessel formation.
This study demonstrates that SUMO protein abundance positively correlates with and functionally regulates meiotic crossover rates across diverse vertebrate species and within goat breeds, establishing SUMO as a central mediator of genetic diversity and chromosome segregation.
This study demonstrates that the newly synthesized organotin(IV) dithiocarbamate DioSn-2 exhibits potent and selective cytotoxicity against A549 lung cancer cells by inducing mitochondria-mediated apoptosis through oxidative stress and caspase-9 activation, positioning it as a promising alternative to cisplatin.
This study reveals that in budding yeast, chronic hyperosmotic stress triggers an adaptive response characterized by Dga1-dependent triacylglycerol synthesis and a shift toward phosphatidylcholine-rich membrane composition, both of which are essential for maintaining cellular fitness.
This study identifies the sodium-bicarbonate cotransporter NBCn1 as a critical ciliary membrane component that interacts with DYNLL1 to regulate ciliary length and SUFU localization, thereby controlling Sonic hedgehog signaling.
This study reveals that the deubiquitinase inhibitor VLX-1570 and DNA damage both trigger the ubiquitin-dependent recruitment of SLFN11 to chromatin via RNF168-mediated K27-linked polyubiquitination of specific lysine residues in its linker domain, leading to transcriptional suppression at promoter regions.
This study reveals that centriolar satellites, through the proteins CEP131 and the RNA-binding protein Unkempt, regulate the microtubule-dependent localization and stabilization of CEP350 mRNA at centrosomes, a pathway essential for CEP350 protein accumulation, PLK4-induced centriole overduplication, and centrosome amplification in triple-negative breast cancer cells.
This study reveals that fission yeast eliminates invasive exogenous DNA by utilizing RNAi to recruit heterochromatin, which triggers asymmetric mitotic partitioning driven by the hypoactivity of Aurora B kinase on plasmids, thereby establishing a novel cell-autonomous immune mechanism to distinguish self from non-self DNA.
The paper introduces LUCID-EV, a robust and quantitative bioluminescent assay using HiBiT/LgBiT complementation that enables the detection of cytosolic delivery from non-VSV-G-expressing extracellular vesicles into target immune cells without relying on artificial fusogenic proteins.
This study reveals that fasting reverses PLN R14del-mediated cardiomyopathy by reactivating impaired lysosomal function, which clears accumulated sarcoplasmic reticulum-derived vesicles and restores microtubule integrity and cellular organization in cardiomyocytes.
This paper argues that transient mitochondrial depolarization events, known as "flickers," likely represent a regulated physiological signaling mechanism within dynamic bioenergetic networks rather than mere indicators of damage, emphasizing the need for rigorous imaging methods to distinguish these events from experimental artifacts.
By utilizing intravital imaging through a titanium window in an immunodeficient mouse model, researchers demonstrated that ectopically implanted humanised bone marrow scaffolds undergo dynamic extracellular matrix remodelling and vascularisation to support human haematopoietic cell development, establishing a novel, longitudinal platform for in vivo bone marrow studies.
This study demonstrates that acute exposure to the environmental pollutant PFOS disrupts membrane fluidity and lipid homeostasis in human fallopian tube epithelial cells, triggering stress-response signaling pathways that impair cell adhesion, proliferation, and epithelial integrity.
This study utilizes metabolomics to analyze human RPE-choroid tissue, revealing that metabolic changes associated with aging, particularly elevated levels of trimethylamine N-oxide and uric acid, are more pronounced than those linked to specific stages of age-related macular degeneration, with functional assays suggesting uric acid may impair endothelial cell migration.
Nup358 maintains intestinal epithelial homeostasis by preventing Dvl1 phase separation, thereby inhibiting constitutive Wnt signaling activation and ensuring the proper differentiation and survival of transit-amplifying progenitor cells.
This study reveals that the ribosomal protein paralog Rpl12b specifically regulates TORC1 signaling and Stm1 expression to control ribosome stability, stress adaptation, and cellular longevity in *Saccharomyces cerevisiae*.
By combining CRISPR-Cas9 gene editing with live-cell imaging and proximity labeling, this study reveals that GGAs localize to distinct Golgi and peripheral compartments where they independently recruit clathrin and regulate AP-1-dependent trafficking by preventing premature AP-1 binding to its cargo, thereby modulating bi-directional transport between the Golgi and endosomes.
This study demonstrates that the interplay between the severing enzyme katanin, minus-end stabilizers CAMSAPs and WDR47, and the depolymerase kinesin-13 fine-tunes microtubule minus-end stability and abundance through a concentration-dependent balance of amplification and disassembly.
This study reveals that the fission yeast cyclin Cdc13 is regulated post-transcriptionally via a specific 20-amino-acid motif to achieve size-dependent protein expression, yet demonstrates that this size-dependent regulation is not essential for cell size control.
This study demonstrates that in LMNA-related dilated cardiomyopathy, nuclear envelope rupture in cardiomyocytes triggers cytosolic DNA sensing and maladaptive immune-fibrotic interactions, leading to disease progression that can be reversed by disrupting the LINC complex to prevent nuclear damage.